Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution. García-León MJ, Mosquera M, Cela C, Alcain J, Zuklys S, Holländer G, Toribio ML. Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells. Van der Stegen SJC, Lindenbergh PL, Petrovic RM, Xie H, Diop MP, Alexeeva V, Shi Y, Mansilla-Soto J, Hamieh M, Eyquem J, Cabriolu A, Wang X, Abujarour R, Lee T, Clarke R, Valamehr B, Themeli M, Riviere I, Sadelain M. Development of γδ T cells in the thymus - A human perspective. Transcriptional regulation of Notch1 by nuclear factor-κB during T cell activation. Hwang JR, Kim D, Kang JA, Park SH, Park SG. Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF. Liang KL, Roels J, Lavaert M, Putteman T, Boehme L, Tilleman L, Velghe I, Pegoretti V, Van de Walle I, Sontag S, Vandewalle J, Vandekerckhove B, Leclercq G, Van Vlierberghe P, Libert C, Van Nieuwerburgh F, Fischer R, Kontermann RE, Pfizenmaier K, Doody G, Zenke M, Taghon T. An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells. We can inspect your entire premises, including your fixed ladders, and provide either recertification or advice on how to bring your site up to standard, allowing you to feel safe in the knowledge that anyone working on it is safe and sound.įor more information on our recertification services, click here, or call us on 01.Van de Walle I, De Smet G, De Smedt M, Vandekerckhove B, Leclercq G, Plum J, Taghon T. Roof Edge inspects and recertifies hundreds of sites each year, and our experienced survey teams can highlight issues that even the most dedicated untrained inspector can miss. This is why we recommend having your fixed ladder inspected for suitability and compliance by a dedicated third party. If this were to be picked up during a HSE inspection, and you have done nothing to remedy it, you might find yourself in hot water. Many people are unaware of these regulations, and a standard inspection – even by a competent person – may not highlight that the fixed ladder is unsuitable for use due to non-compliance. Clear space on the user side should be 600mm.A minimum of 200mm clear space should be behind each rung.Rise between rungs should be 225mm to 300mm.The top rung should be level with the platform.Rungs must withstand 1.5kN and have a diameter of 20-35mm.Handrails should open out to between 600mm and 700mm above the landing.The width between the strings should be between 300mm (400mm preferred) and 600mm.Hoops should not exceed 1500mm apart with uprights not more than 300mm apart.Hoops should be a maximum of 900mm apart.Fall protection, preferably passive such as cages, should be provided if there is a risk of falling more than 2m. Hoops should be fixed if the ladder exceeds 2.5m.The ladder should not exceed 6m without an intermediate landing.Stiles should extend to the height of guarding.Handrails should extend at least 1100mm above landing.Assembly should be sufficiently rigid and stable to ensure safety of the user under normal conditions.The ladder should be of sound construction, properly maintained and securely fixed.Fixed ladders should not be used where it would be practical to install a conventional staircase.If your ladder does not meet these criteria, it could be a glaring danger to everyone on your site, as well as visitors.Īccording to the Workplace (Health, Safety and Welfare) Regulations, ACOP and BS4211, these criteria are: However, this highlights another common issue: no matter how often you check your ladder for failures, there’s a chance it was never even safe to begin with.īeyond the standard inspection criteria for use, there are a set of criteria that must be met for the ladder to be deemed compliant to start with. Ladders contribute to a large number of work at height injury and fatality statistics each year. It is a common misconception that fixed ladders do not need to be inspected, and this can lead to serious injury or worse if a ladder falls into disrepair and someone tries to use it. Last month, we wrote about an issue many people tend to neglect: the inspection and recertification of fixed ladders.
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